ISSN 1301 - 0883 / E-ISSN 1339 - 3886
 
 







 
 
Search





Simple Peripheral Markers for Inflammation in Drug-Naive, Comorbidity-Free Adolescents with Obsessive–Compulsive Disorder [Eastern J Med]
Eastern J Med. 2019; 24(1): 23-29 | DOI: 10.5505/ejm.2019.50455  

Simple Peripheral Markers for Inflammation in Drug-Naive, Comorbidity-Free Adolescents with Obsessive–Compulsive Disorder

Halit Necmi Uçar1, Duygu Murat2, Þafak Eray3
1Department of Child and Adolescent Psychiatry, Van Training and Research Hospital, Van, Turkey
2Department of Child and Adolescent Psychiatry, Avcýlar Hospital, Ýstanbul, Turkey
3Department of Child and Adolescent Psychiatry, School of Medicine, University of Uludag

INTRODUCTION: Obsessive Compulsive Disorder (OCD) is a psychiatric disorder which has different etiopathogenic mechanisms. One of these mechanisms is immunologic factors. Studies on immunologic factors, various cytokines and cellular elements were investigated. In order to evaluate the immunological factors in psychiatric disorders, a simple and inexpensive method, hemogram parameters have been investigated. We aimed to evaluate hemogram parameters in drug-naive, comorbidity-free adolescents with OCD comparing with controls.
METHODS: A total of 31 patients diagnosed with OCD, who do not have comorbid diseases and do not take any medical therapy within the past one month, were included in the study. The control group consisted of 47 healthy subjects with no organic and psychiatric disorders.
RESULTS: Lymphocytes, RDW, platelets, and PCT values of the adolescents with OCD were significantly lower than those of the control group. There were no differences between the two groups in terms of WBC, hemoglobin, RBC, HCT, MCV, MCH, MCHC, MPV, Neutrophils, neutrophil–lymphocyte ratio, and platelet-lymphocyte ratio.
DISCUSSION AND CONCLUSION: The findings of the study reveal that lymphocytes and RDW tend to be lower in adolescents with OCD. The findings of our study are consistent with those of previous studies, indicating decreased hemogram parameters associated with inflammation in adolescents with OCD. Our study suggest that we need further study to fully understand the role of inflammation in the etiology and treatment of OCD, and follow-up studies should focus on the process of inflammation in psychiatric diseases in children and adolescents.

Keywords: Obsessive–compulsive disorder, adolescent, inflammation, hemogram parameters, lymphocytes.


Halit Necmi Uçar, Duygu Murat, Þafak Eray. Simple Peripheral Markers for Inflammation in Drug-Naive, Comorbidity-Free Adolescents with Obsessive–Compulsive Disorder. Eastern J Med. 2019; 24(1): 23-29

Corresponding Author: Þafak Eray, Türkiye


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




 
Copyright © 2019 Eastern Journal of Medicine. All Rights Reserved.
Home        |        Contact
LookUs & OnlineMakale