Relationship Between Calcium Metabolism Parameters

INTRODUCTION: Blood calcium is under very tight control in a narrow range of 8.5-10.5 mg / dl. We aimed to investigate the factors that contributed to this control.
METHODS: 464 females and 254 males aged 16-96 years were examined retrospectively. PTH, 25OH vitamin D, Ca, Mg, P and spot urine calcium, creatinine levels were examined.
RESULTS: The rates were as follow; hypercalcemia 5.6%, primary hyperparathyroidism 10.4%, secondary hyperparathyroidism 40.8%, tertiary hyperparathyroidism 17.5%, normal PTH hypercalcemia 1.25%, hypocalcemia 13.5%, hypoparathyroidism 3.7%, hypovitaminosis D 77.6%, hypophosphatemia 6.4%, hyperphosphatemia 17.5%, hypomagnesemia 17.5%, hypermagnesemia 10.4%.
Severe vitamin D deficiency was 37% (n: 172) in females and 20% (n: 53) in males (p <0.01). Urinary Ca and urine creatinine 25 OH vitamin D cut-off value was 10 ng / ml and it was 13ng / ml for PTH. While vitamin D was 10-20 ng / ml, urine Ca / creatinine ratio was lowest and it increased after 20 ng / ml in females and 30 ng / ml in males. There was a negative correlation with PTH as Ca decreased from 8.3 mg / dl and a positive correlation when it increased above 9.2 mg / dl. Mg correlated positively with PTH, Ca and P (p: 0.00 r: 0.23, p: 0.007 r: 0.13, p: 0.00 r: 0.21, respectively).

DISCUSSION AND CONCLUSION: Mg was found to be significantly correlated with all parameters and 25 OH vitamin D was not correlated with any parameters. On the other hand, we have determined the threshold values where the parameters interact with each other.