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The co-occurrence of Guillain-Barré syndrome and inappropriate ADH syndrome in a Rheumatoid arthritis patient [Eastern J Med]
Eastern J Med. 2014; 19(1): 44-46

The co-occurrence of Guillain-Barré syndrome and inappropriate ADH syndrome in a Rheumatoid arthritis patient

Refah Sayın1, Ahmet Cumhur Dülger2, Mehmet Atilla Erkuzu1, Temel Tombul1, Bünyamin Sertoğullarından3
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Rheumatoid Arthritis (RA) is the most frequently seen connective tissue disorder. In RA, the peripheral nervous system involvements including distal sensory or sensorimotor polyneuropathy and entrapment neuropathies are more common than the central nervous system involvements. Guillain-Barré syndrome (GBS), an autoimmune disorder, can be encountered in any age groups. The syndrome of inappropriate secretion of ADH (SIADH) is characterized by the non-physiologic release of ADH, resulting in impaired water excretion with normal sodium excretion that causes hyponatremia. Herein, we present the co-occurrence GBS and SIADH in a RA patient treated with Methotrexate (Mtx). A 57 year-old female developed ascending weakness, starting from the legs and spreading to the arms while having pneumonia. Electromyography findings were consistent with sensorimotor demyelinating polyneuropathy. The laboratory investigations were compatible with SIADH. In conclusion, the SIADH in GBS should be taken into account for RA patients on Mtx.

Keywords: Methotrexate, Guillain-Barré syndrome, syndrome of inappropriate ADH, Rheumatoid arthritis


Refah Sayın, Ahmet Cumhur Dülger, Mehmet Atilla Erkuzu, Temel Tombul, Bünyamin Sertoğullarından. The co-occurrence of Guillain-Barré syndrome and inappropriate ADH syndrome in a Rheumatoid arthritis patient. Eastern J Med. 2014; 19(1): 44-46


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