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Is there a mortality effect of emipiric colistin in the treatment of acinetobacter baumanni? [Eastern J Med]
Eastern J Med. 2019; 24(4): 405-411 | DOI: 10.5505/ejm.2019.25743  

Is there a mortality effect of emipiric colistin in the treatment of acinetobacter baumanni?

İlhan Bahar1, Gülseren Elay2
1İlhan BAHAR Katip Çelebi University, Atatürk Education and Research Hospital Internal Intensive Care, Izmir, Turkey,
2Gülseren ELAY Ersin Aslan Training and Research Hospital Intensive Care Anesthesiology, Gaziantep, Turkey

INTRODUCTION: To investigate the effect of empirical or culture based colistin therapy on the mortality of intensive care medicine (ICU) patients with severe sepsis and septic shock
METHODS: Patients with severe sepsis and septic shock treated in three Intensive Care Units of medical faculty of Erciyes University were included in this retrospective, descriptive study. Sixty-nine patients were included in this study. The empirical group (Group 1) consisted of 33 (47%) patients; Group 2 consisted of 36 (53%) patients.
RESULTS: Results: The baseline Acute Physiology and Chronic Health Evaluation II (APACHE II) scores were significantly higher in the empirical group (p = 0.01). However, the groups did not differ regarding the pre-treatment Sepsis-related Organ Failure Assessment (SOFA) scores (p=0.92). The groups did not differ regarding the mean duration of intensive care stay (15 days vs. 20 days, p = 0.20) or in terms of the intensive care mortality (58.3% vs. 72.7%, p = 0.31). There was also no difference between the groups in 30-day in hospital mortality (61.1% vs. 78.8%, p = 0.12).
DISCUSSION AND CONCLUSION: In patients with severe sepsis/septic shock, there were no differences between the groups in which the colistin therapy was initiated empirically or based on sensitivity test results.

Keywords: Sepsis, Acinetobacter baumannii, colistin, mortality


İlhan Bahar, Gülseren Elay. Is there a mortality effect of emipiric colistin in the treatment of acinetobacter baumanni?. Eastern J Med. 2019; 24(4): 405-411

Corresponding Author: İlhan Bahar, Türkiye


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