ISSN 1301 - 0883 / E-ISSN 1309 - 3886
 
 








  Comparison of the efficacy of letrozole and gonadotropin combination versus gonadotropin alone in intrauterine insemination cycles in patients with unexplained infertility [Eastern J Med]
Eastern J Med. 2020; 25(3): 427-433 | DOI: 10.5505/ejm.2020.24993  

Comparison of the efficacy of letrozole and gonadotropin combination versus gonadotropin alone in intrauterine insemination cycles in patients with unexplained infertility

Süleyman Cemil Oğlak1, Mehmet Nafi Sakar2, Serhat Ege1, Serap Mutlu Özçelik Otçu1, Mehmet Obut3, Bekir Kahveci4, İsmail Yıldız5
1Health Sciences University, Diyarbakır Gazi Yaşargil Training And Research Hospital, Department Of Obstetrics And Gynaecology, Diyarbakır, Turkey
2Memorial Diyarbakır Hospital, Department of Obstetrics and Gynecology, Diyarbakır, Turkey
3Etlik Zübeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey
4Çukurova University School Of Medicine, Department Of Obstetrics And Gynaecology, Adana, Turkey
5Dicle University School Of Medicine, Department Of Biostatistics, Diyarbakır, Turkey

INTRODUCTION: This study aimed to determine the outcomes of combined treatment of letrozole (LTZ) with recombinant follicle-stimulating hormone (rFSH) in comparison with rFSH alone in intrauterine insemination (IUI) cycles.
METHODS: This study consisted of 86 patients who experienced 106 IUI cycles. Patients were classified into two treatment groups: group I underwent a combination of LTZ plus rFSH, and group II received rFSH alone. Ovulation was triggered with human chorionic gonadotropin (hCG), and IUI performed 36 hours later. The number of follicles ≥18 mm, endometrial thickness, required dose of FSH, duration of ovulation induction (OI), clinical pregnancy rates, multiple pregnancy rates, spontaneous abortion rates, and live birth rates were evaluated.
RESULTS: The total required rFSH dose during the OI was significantly lower in the LTZ-rFSH combination group than the rFSH alone group (401.2±177.1 IU and 770.1±345.8 IU, respectively, p<0.001). The days of stimulation with rFSH were also lower in the LTZ co-treatment group than the rFSH-alone group (5.2±1.3 days and 10.1±3.0 days, respectively, p<0.001). Clinical pregnancy rate was 17.0% in LTZ-rFSH group, and 15.2% in rFSH group (p>0.05).
DISCUSSION AND CONCLUSION: The combined use of LTZ with rFSH resulted in a lower required dose of rFSH, a similar and acceptable endometrial thickness at the day of hCG administration, and comparable pregnancy rate compared with rFSH alone.

Keywords: Letrozole, gonadotropin, ovulation induction, intrauterine insemination.


Süleyman Cemil Oğlak, Mehmet Nafi Sakar, Serhat Ege, Serap Mutlu Özçelik Otçu, Mehmet Obut, Bekir Kahveci, İsmail Yıldız. Comparison of the efficacy of letrozole and gonadotropin combination versus gonadotropin alone in intrauterine insemination cycles in patients with unexplained infertility. Eastern J Med. 2020; 25(3): 427-433

Corresponding Author: Süleyman Cemil Oğlak, Türkiye


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