Advance stage small cell neuroendocrine carcinoma of cervix: A case report

Neuroendocrine small cell carcinoma of the uterine cervix is an entity with very aggressive behaviour. The optimal initial therapeutic approach to this rare disease has not yet been clearly defined. These tumors are difficult to manage. It is often diagnosed at an advanced stage and its prognosis is generally poor. In this paper, a 44-year-old woman with small cell neuroendocrine tumor of the cervix presenting with widespread metastasis is reported. Literature provides limited research on the issue and the reported research involves only small series and case reports on neuroendocrine small cell cervical carcinoma. Neuroendocrine differentiation can be shown by several methods. The most important of all these methods is immunohistochemical study. Surgery, radiotherapy, and chemotherapy have been used either alone or in combination. The purpose of this case is to evaluate this rarely seen, aggressive, malignant cervical tumor with poor prognosis, and thus, make some contribution to the literature.