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Expression profiles of TRAIL and its receptors in normal, hyperplastic, and malignant endometrial tissues: Hints on endometrial cancer biology [Eastern J Med]
Eastern J Med. 2019; 24(3): 361-370 | DOI: 10.5505/ejm.2019.21447  

Expression profiles of TRAIL and its receptors in normal, hyperplastic, and malignant endometrial tissues: Hints on endometrial cancer biology

Cigdem Aydin1, Atil Bisgin3, Ahter Dilsad Sanlioglu2, Elif Pestereli4, Gulgun Erdogan4, Irem Hicran Ozbudak4, Tayup Simsek5, Salih Sanlioglu2
1Bucak School of Health, Mehmet Akif Ersoy University, Burdur, Turkey
2Department of Medical Biology And Genetics, Faculty of Medicine, Akdeniz University, Antalya, Turkey
3Department of Medical Genetics, Faculty of Medicine, Cukurova University, Adana, Turkey
4Department of Pathology, Faculty of Medicine, Akdeniz University, Antalya, Turkey
5Department of Gynecology And Obstetrics, Faculty of Medicine, Akdeniz University, Antalya, Turkey

INTRODUCTION: Endometrial cancer is the sixth most common neoplasm in women worldwide, with a rising incidence largely attributed to the ongoing obesity epidemic. TNF-Related Apoptosis-Inducing Ligand (TRAIL) and TRAIL receptors have been tested for their predictive, diagnostic, and prognostic values in various cancers, as well as for possible use in combination therapies. The roles of TRAIL and its receptors in endometrial tissue biology has not yet been cleared, and the potential of these molecules as biomarkers in endometrial cancer is yet to be defined. We investigated the expression profiles of TRAIL and its transmembrane receptors during endometrial carcinogenesis to evaluate their potential as prognostic markers.
METHODS: Paraffin-embedded normal endometrium (n=18), endometrial hyperplasia (n=27), and endometrioid endometrial adenocarcinoma tissues (n=100) were analysed for TRAIL and receptor expression profiles via immunohistochemical staining. Apoptotic indexes in the corresponding tissues were defined by TUNEL assay.
RESULTS: Endometrial carcinoma displayed decreased TRAIL and DR4 expressions compared to the normal endometrium, while increased DR5 and decoy receptor (DcR1 and DcR2) expressions were evident. The complex atypical hyperplasia displayed the most similar expression profiles to the endometrial carcinoma, in accordance with the greatest risk of progression to endometrial carcinoma attributed to this tissue type. TRAIL/TRAIL receptor expression levels did not correlate with the prognostic factors of tumor stage or grade, or depth of myometrial invasion.
DISCUSSION AND CONCLUSION: Overall, distinct profiles of TRAIL and its receptor expressions were evident in progression from normal endometrium to hyperplasia and cancer, which may indicate significance of TRAIL signaling in the course of endometrial carcinoma development.

Keywords: Normal endometrium, Endometrial Hyperplasia, Endometrial Carcinoma, TRAIL, DR4, DR5, DcR1, DcR2


Cigdem Aydin, Atil Bisgin, Ahter Dilsad Sanlioglu, Elif Pestereli, Gulgun Erdogan, Irem Hicran Ozbudak, Tayup Simsek, Salih Sanlioglu. Expression profiles of TRAIL and its receptors in normal, hyperplastic, and malignant endometrial tissues: Hints on endometrial cancer biology. Eastern J Med. 2019; 24(3): 361-370

Corresponding Author: Cigdem Aydin, Türkiye


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