ISSN 1301 - 0883 / E-ISSN 1309 - 3886
 
 








  The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey [Eastern J Med]
Eastern J Med. 2020; 25(3): 350-355 | DOI: 10.5505/ejm.2020.05945  

The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey

Gonca Gulbay1, Elif Yesilada1, MEHMET ALI ERKURT2, Harika Gozde Gozukara Bag3
1Department of Medical Genetics, Faculty of Medicine, Inonu University, Malatya, Turkey
2Department of Hematology, Faculty of Medicine, Inonu University, Malatya, Turkey
3Department of Biostatistics,Faculty of Medicine, Inonu University, Malatya, Turkey

INTRODUCTION: Recurrent balanced translocations are generally considered as the main parameter for prognosis in acute myeloid leukemia (AML). In recent years, genetic studies have focused on the ascertaintment of molecular aspects of various oncofusion proteins associated with AML, such as t(15;17) PML-RARA, t(8;21) RUNX1-RUNX1T1, t(9;22) BCR-ABL1 and inv (16) CBFB-MYH11. Therefore, we evaluated AML cases with RT-PCR for known specific genetic abnormalities that could lead to more accurate prognosis.
METHODS: In our study, we retrospectively reviewed the records of 211 cases (59.2% males and 40.8% females). RT-PCR technique was performed to identify t(15;17) PML-RARA, t(8;21) RUNX1-RUNX1T1, t(9;22) BCR-ABL1 and inv (16) CBFB-MYH11.
RESULTS: The most common rearrangement was found to be t (15; 17) (%12.8) followed by t (8; 21) (7.11%), t (9; 22) (7.6%) and inv (16) (1.42%). Also, in two other cases (0.95%) t(15;17) and t(8;21) were seen together. In addition, none of these rearrangement were found in 148 cases (70.14%) with AML.
DISCUSSION AND CONCLUSION: The presence of chromosomal rearrangements is very important in the diagnosis of AML. Therefore, rapid identification of specific rearrangements during diagnosis is important for prognostic purposes and can help identify the cause of leukemogenesis and provide new strategies for the treatment of cases. This study will be a baseline reference for future analysis and epidemiological data useful for transplant centers and oncologists both in Turkey and the region.

Keywords: Acute myeloid leukemia, PML-RARA, RUNX1-RUNX1T1, BCR-ABL1, CBFB-MYH11


Gonca Gulbay, Elif Yesilada, MEHMET ALI ERKURT, Harika Gozde Gozukara Bag. The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey. Eastern J Med. 2020; 25(3): 350-355

Corresponding Author: Gonca Gulbay, Türkiye


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




 
Copyright © 2020 Eastern Journal of Medicine. All Rights Reserved.
Home        |        Contact
LookUs & OnlineMakale